Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4% of total α-synuclein is phosphorylated a...

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Detalles Bibliográficos
Autores principales: Arawaka, Shigeki, Sato, Hiroyasu, Sasaki, Asuka, Koyama, Shingo, Kato, Takeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472914/
https://www.ncbi.nlm.nih.gov/pubmed/28619113
http://dx.doi.org/10.1186/s40478-017-0452-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472914/
https://www.ncbi.nlm.nih.gov/pubmed/28619113
http://dx.doi.org/10.1186/s40478-017-0452-6

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