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Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4% of total α-synuclein is phosphorylated a...

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Detalles Bibliográficos
Autores principales:	Arawaka, Shigeki, Sato, Hiroyasu, Sasaki, Asuka, Koyama, Shingo, Kato, Takeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472914/ https://www.ncbi.nlm.nih.gov/pubmed/28619113 http://dx.doi.org/10.1186/s40478-017-0452-6

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