SCnorm: robust normalization of single-cell RNA-seq data

Normalization of RNA-sequencing data is essential for accurate downstream inference, but the assumptions upon which most methods are based do not hold in the single-cell setting. Consequently, applying existing normalization methods to single-cell RNA-seq data introduces artifacts that bias downstre...

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Detalles Bibliográficos
Autores principales: Bacher, Rhonda, Chu, Li-Fang, Leng, Ning, Gasch, Audrey P., Thomson, James A., Stewart, Ron M., Newton, Michael, Kendziorski, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473255/
https://www.ncbi.nlm.nih.gov/pubmed/28418000
http://dx.doi.org/10.1038/nmeth.4263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473255/
https://www.ncbi.nlm.nih.gov/pubmed/28418000
http://dx.doi.org/10.1038/nmeth.4263

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