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SCnorm: robust normalization of single-cell RNA-seq data
Normalization of RNA-sequencing data is essential for accurate downstream inference, but the assumptions upon which most methods are based do not hold in the single-cell setting. Consequently, applying existing normalization methods to single-cell RNA-seq data introduces artifacts that bias downstre...
Autores principales: | Bacher, Rhonda, Chu, Li-Fang, Leng, Ning, Gasch, Audrey P., Thomson, James A., Stewart, Ron M., Newton, Michael, Kendziorski, Christina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473255/ https://www.ncbi.nlm.nih.gov/pubmed/28418000 http://dx.doi.org/10.1038/nmeth.4263 |
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