Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca(2+)-permeable non-selective cation channel activated by the binding of adenosine 5′-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain (NUDT9 homology domain). Activation of TRPM2 by ADPR downstream of oxidativ...

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Detalles Bibliográficos
Autores principales: Fliegert, Ralf, Watt, Joanna M., Schöbel, Anja, Rozewitz, Monika D., Moreau, Christelle, Kirchberger, Tanja, Thomas, Mark P., Sick, Wiebke, Araujo, Andrea C., Harneit, Angelika, Potter, Barry V.L., Guse, Andreas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473349/
https://www.ncbi.nlm.nih.gov/pubmed/28515263
http://dx.doi.org/10.1042/BCJ20170091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473349/
https://www.ncbi.nlm.nih.gov/pubmed/28515263
http://dx.doi.org/10.1042/BCJ20170091

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