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Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K mRNAs encoding essential components of the U12-type intron-specific U11/U12 di-snRNP. This involves interaction of the U11 snRNP with an evolutionarily conserved splicing enha...
Autores principales: | Verbeeren, Jens, Verma, Bhupendra, Niemelä, Elina H., Yap, Karen, Makeyev, Eugene V., Frilander, Mikko J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473595/ https://www.ncbi.nlm.nih.gov/pubmed/28549066 http://dx.doi.org/10.1371/journal.pgen.1006824 |
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