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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
Acetylation of Atg3 regulates the lipidation of the protein Atg8 in autophagy. The molecular mechanism behind this important biochemical event remains to be elucidated. We describe the first semi-synthesis of homogeneous K19/K48-diacetylated Atg3 through sequential hydrazide-based native chemical li...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473643/ https://www.ncbi.nlm.nih.gov/pubmed/28327644 http://dx.doi.org/10.1038/ncomms14846 |