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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

Acetylation of Atg3 regulates the lipidation of the protein Atg8 in autophagy. The molecular mechanism behind this important biochemical event remains to be elucidated. We describe the first semi-synthesis of homogeneous K19/K48-diacetylated Atg3 through sequential hydrazide-based native chemical li...

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Detalles Bibliográficos
Autores principales:	Li, Yi-Tong, Yi, Cong, Chen, Chen-Chen, Lan, Huan, Pan, Man, Zhang, Shao-Jin, Huang, Yi-Chao, Guan, Chao-Jian, Li, Yi-Ming, Yu, Li, Liu, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473643/ https://www.ncbi.nlm.nih.gov/pubmed/28327644 http://dx.doi.org/10.1038/ncomms14846

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