Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution of this peptide, it was conjugated with NOTA and radiolabel...

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Detalles Bibliográficos
Autores principales: Bergmann, Ralf, Kubeil, Manja, Zarschler, Kristof, Chhabra, Sandeep, Tajhya, Rajeev B., Beeton, Christine, Pennington, Michael W., Bachmann, Michael, Norton, Raymond S., Stephan, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473807/
https://www.ncbi.nlm.nih.gov/pubmed/28623364
http://dx.doi.org/10.1038/s41598-017-03998-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473807/
https://www.ncbi.nlm.nih.gov/pubmed/28623364
http://dx.doi.org/10.1038/s41598-017-03998-x

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