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Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains

The precise mechanisms through which insoluble, cell-adhesive ligands induce and regulate directional cell migration remain obscure. We recently demonstrated that elevated surface density of physically adsorbed plasma fibronectin (FN) promotes high directional persistence in fibroblast migration. Wh...

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Detalles Bibliográficos
Autores principales: Missirlis, Dimitris, Haraszti, Tamás, Kessler, Horst, Spatz, Joachim P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473823/
https://www.ncbi.nlm.nih.gov/pubmed/28623309
http://dx.doi.org/10.1038/s41598-017-03701-0