Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap

Angiopoietin-1 (Angpt1) is a glycoprotein ligand important for maintaining the vascular system. It signals via a receptor tyrosine kinase expressed on the surface on endothelial cells, Tie2. This receptor can undergo regulated ectodomain cleavage that releases the ligand-binding domain (sTie2) into...

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Detalles Bibliográficos
Autores principales: Alawo, Deborah O. A., Tahir, Tariq A., Fischer, Marlies, Bates, Declan G., Amirova, Svetlana R., Brindle, Nicholas P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473842/
https://www.ncbi.nlm.nih.gov/pubmed/28623351
http://dx.doi.org/10.1038/s41598-017-03981-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473842/
https://www.ncbi.nlm.nih.gov/pubmed/28623351
http://dx.doi.org/10.1038/s41598-017-03981-6

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