Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons

Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein interactions with Toll/Interleukin-1 Receptor (TIR) domains present in sensory neurons may modulate neuropathic pain states. Following ligand interaction with TLRs, TIR serves to both initiate intracellular signa...

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Detalles Bibliográficos
Autores principales: Allette, Yohance M., Kim, Youngsook, Randolph, Aaron L., Smith, Jared A., Ripsch, Matthew S., White, Fletcher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473853/
https://www.ncbi.nlm.nih.gov/pubmed/28623271
http://dx.doi.org/10.1038/s41598-017-03447-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473853/
https://www.ncbi.nlm.nih.gov/pubmed/28623271
http://dx.doi.org/10.1038/s41598-017-03447-9

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