Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells

The non-canonical initiation factors DENR and MCTS1 have been linked to cancer and autism. We recently showed in Drosophila that DENR and MCTS1 regulate translation re-initiation on transcripts containing upstream Open Reading Frames (uORFs) with strong Kozak sequences (stuORFs). Due to the medical...

Descripción completa

Detalles Bibliográficos
Autores principales: Schleich, Sibylle, Acevedo, Julieta M., Clemm von Hohenberg, Katharina, Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473865/
https://www.ncbi.nlm.nih.gov/pubmed/28623304
http://dx.doi.org/10.1038/s41598-017-03949-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473865/
https://www.ncbi.nlm.nih.gov/pubmed/28623304
http://dx.doi.org/10.1038/s41598-017-03949-6

Ejemplares similares