Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter

Dopamine transporter (DAT) is the target of cocaine and HIV-1 transactivator of transcription (Tat) protein. Identifying allosteric modulatory molecules with potential attenuation of cocaine and Tat binding to DAT are of great scientific and clinical interest. We demonstrated that tyrosine 470 and 8...

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Detalles Bibliográficos
Autores principales: Sun, Wei-Lun, Quizon, Pamela M., Yuan, Yaxia, Zhang, Wei, Ananthan, Subramaniam, Zhan, Chang-Guo, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473888/
https://www.ncbi.nlm.nih.gov/pubmed/28623359
http://dx.doi.org/10.1038/s41598-017-03771-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473888/
https://www.ncbi.nlm.nih.gov/pubmed/28623359
http://dx.doi.org/10.1038/s41598-017-03771-0

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