MicroRNA-34a Encapsulated in Hyaluronic Acid Nanoparticles Induces Epigenetic Changes with Altered Mitochondrial Bioenergetics and Apoptosis in Non-Small-Cell Lung Cancer Cells

Therapies targeting epigenetic changes for cancer treatment are in Phase I/II trials; however, all of these target only nuclear DNA. Emerging evidence suggests presence of methylation marks on mitochondrial DNA (mtDNA); but their contribution in cancer is unidentified. Expression of genes encoded on...

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Detalles Bibliográficos
Autores principales: Trivedi, Malav, Singh, Amit, Talekar, Meghna, Pawar, Grishma, Shah, Parin, Amiji, Mansoor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473901/
https://www.ncbi.nlm.nih.gov/pubmed/28623259
http://dx.doi.org/10.1038/s41598-017-02816-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473901/
https://www.ncbi.nlm.nih.gov/pubmed/28623259
http://dx.doi.org/10.1038/s41598-017-02816-8

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