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Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates

We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH(3))(2)Cl(2)(OA)(2)] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center. Our results demonstrate that Pt(IV)diOA is a potent cytotoxi...

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Detalles Bibliográficos
Autores principales:	Novohradsky, Vojtech, Zanellato, Ilaria, Marzano, Cristina, Pracharova, Jitka, Kasparkova, Jana, Gibson, Dan, Gandin, Valentina, Osella, Domenico, Brabec, Viktor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473904/ https://www.ncbi.nlm.nih.gov/pubmed/28623355 http://dx.doi.org/10.1038/s41598-017-03864-w

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