Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors

Despite the major role of Gag in establishing resistance of HIV-1 to protease inhibitors (PIs), very limited data are available on the total contribution of Gag residues to resistance to PIs. To identify in detail Gag residues and structural interfaces associated with the development of HIV-1 resist...

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Detalles Bibliográficos
Autores principales: Codoñer, Francisco M, Peña, Ruth, Blanch-Lombarte, Oscar, Jimenez-Moyano, Esther, Pino, Maria, Vollbrecht, Thomas, Clotet, Bonaventura, Martinez-Picado, Javier, Draenert, Rika, Prado, Julia G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473930/
https://www.ncbi.nlm.nih.gov/pubmed/28623276
http://dx.doi.org/10.1038/s41598-017-03260-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473930/
https://www.ncbi.nlm.nih.gov/pubmed/28623276
http://dx.doi.org/10.1038/s41598-017-03260-4

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