Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we present a cryoelectron microscopy struc...

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Detalles Bibliográficos
Autores principales: Zhang, Kai, Foster, Helen E., Rondelet, Arnaud, Lacey, Samuel E., Bahi-Buisson, Nadia, Bird, Alexander W., Carter, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473941/
https://www.ncbi.nlm.nih.gov/pubmed/28602352
http://dx.doi.org/10.1016/j.cell.2017.05.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473941/
https://www.ncbi.nlm.nih.gov/pubmed/28602352
http://dx.doi.org/10.1016/j.cell.2017.05.025

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