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Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated
Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we present a cryoelectron microscopy struc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473941/ https://www.ncbi.nlm.nih.gov/pubmed/28602352 http://dx.doi.org/10.1016/j.cell.2017.05.025 |