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ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

INTRODUCTION: Matrix metalloproteinases (MMPs) and ‘aggrecanase’ a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potent...

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Detalles Bibliográficos
Autores principales: Yang, C.-Y., Chanalaris, A., Troeberg, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473942/
https://www.ncbi.nlm.nih.gov/pubmed/28216310
http://dx.doi.org/10.1016/j.joca.2017.02.791