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Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection

Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. Cancer cells alter...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Kiran, Billaud, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474466/
https://www.ncbi.nlm.nih.gov/pubmed/28674522
http://dx.doi.org/10.3389/fendo.2017.00136
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author Padmanabhan, Kiran
Billaud, Marc
author_facet Padmanabhan, Kiran
Billaud, Marc
author_sort Padmanabhan, Kiran
collection PubMed
description Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. Cancer cells alter their metabolic state and gene expression and therefore are likely to tweak circadian clock function in their favor. Over the past decade, we have witnessed an extraordinary increase in systems-level studies that suggest intricate mechanistic links between the cellular metabolome and the circadian epigenome. In parallel, reprogramming of cellular clock function in cancers is increasingly evident and the role of clock genes in the development of hematological tumors, as well as their pathophysiological effects on tissues distal to the tumor, has been described. Furthermore, the interplay between components of the circadian clock, metabolic enzymes, and oncogenes is starting to be better understood, such as the close association between overexpression of the Myc oncogene and perturbation of circadian and metabolic rhythms, thus opening new avenues to treat cancers. This review article explores current knowledge on the circadian metabolome and the molecular pathways they control, with a focus on their involvement in the development of hematopoietic malignancies.
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spelling pubmed-54744662017-07-03 Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection Padmanabhan, Kiran Billaud, Marc Front Endocrinol (Lausanne) Endocrinology Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. Cancer cells alter their metabolic state and gene expression and therefore are likely to tweak circadian clock function in their favor. Over the past decade, we have witnessed an extraordinary increase in systems-level studies that suggest intricate mechanistic links between the cellular metabolome and the circadian epigenome. In parallel, reprogramming of cellular clock function in cancers is increasingly evident and the role of clock genes in the development of hematological tumors, as well as their pathophysiological effects on tissues distal to the tumor, has been described. Furthermore, the interplay between components of the circadian clock, metabolic enzymes, and oncogenes is starting to be better understood, such as the close association between overexpression of the Myc oncogene and perturbation of circadian and metabolic rhythms, thus opening new avenues to treat cancers. This review article explores current knowledge on the circadian metabolome and the molecular pathways they control, with a focus on their involvement in the development of hematopoietic malignancies. Frontiers Media S.A. 2017-06-19 /pmc/articles/PMC5474466/ /pubmed/28674522 http://dx.doi.org/10.3389/fendo.2017.00136 Text en Copyright © 2017 Padmanabhan and Billaud. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Padmanabhan, Kiran
Billaud, Marc
Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title_full Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title_fullStr Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title_full_unstemmed Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title_short Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection
title_sort desynchronization of circadian clocks in cancer: a metabolic and epigenetic connection
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474466/
https://www.ncbi.nlm.nih.gov/pubmed/28674522
http://dx.doi.org/10.3389/fendo.2017.00136
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