MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL rearranged targets, we investigated the genome-wide binding of the MLL-AF9 and MLL-AF4 fusion proteins and associated epigenetic signature...

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Detalles Bibliográficos
Autores principales: Prange, K H M, Mandoli, A, Kuznetsova, T, Wang, S-Y, Sotoca, A M, Marneth, A E, van der Reijden, B A, Stunnenberg, H G, Martens, J H A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474565/
https://www.ncbi.nlm.nih.gov/pubmed/28114278
http://dx.doi.org/10.1038/onc.2016.488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474565/
https://www.ncbi.nlm.nih.gov/pubmed/28114278
http://dx.doi.org/10.1038/onc.2016.488

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