Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2′‐Deoxypseudoisocytidine

A synthetic procedure for the preparation of phosphoramidate prodrugs of C‐nucleosides is reported. Different phosphorochloridates were reacted with 3′‐O‐protected N‐acetyl‐2′‐deoxypseudoisocytidine or 3′‐O‐protected 2′‐deoxypseudoisocytidine, followed by acidic hydrolysis of the protecting group. I...

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Detalles Bibliográficos
Autores principales: Serpi, Michaela, De Biasi, Roberto, Pertusati, Fabrizio, Slusarczyk, Magdalena, McGuigan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474688/
https://www.ncbi.nlm.nih.gov/pubmed/28638776
http://dx.doi.org/10.1002/open.201700019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474688/
https://www.ncbi.nlm.nih.gov/pubmed/28638776
http://dx.doi.org/10.1002/open.201700019

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