Cellular senescence drives age-dependent hepatic steatosis

The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration...

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Detalles Bibliográficos
Autores principales: Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474745/
https://www.ncbi.nlm.nih.gov/pubmed/28608850
http://dx.doi.org/10.1038/ncomms15691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474745/
https://www.ncbi.nlm.nih.gov/pubmed/28608850
http://dx.doi.org/10.1038/ncomms15691

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