Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?

Fine-mapping to identify causal variants in genome-wide association studies remains challenging. A recent study provides guidance for future research.

Detalles Bibliográficos
Autores principales: Wang, Zhaoming, Chatterjee, Nilanjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474869/
https://www.ncbi.nlm.nih.gov/pubmed/28629446
http://dx.doi.org/10.1186/s13059-017-1255-6
_version_ 1783244517771575296
author Wang, Zhaoming
Chatterjee, Nilanjan
author_facet Wang, Zhaoming
Chatterjee, Nilanjan
author_sort Wang, Zhaoming
collection PubMed
description Fine-mapping to identify causal variants in genome-wide association studies remains challenging. A recent study provides guidance for future research.
format Online
Article
Text
id pubmed-5474869
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54748692017-06-21 Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both? Wang, Zhaoming Chatterjee, Nilanjan Genome Biol Research Highlight Fine-mapping to identify causal variants in genome-wide association studies remains challenging. A recent study provides guidance for future research. BioMed Central 2017-06-19 /pmc/articles/PMC5474869/ /pubmed/28629446 http://dx.doi.org/10.1186/s13059-017-1255-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Wang, Zhaoming
Chatterjee, Nilanjan
Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title_full Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title_fullStr Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title_full_unstemmed Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title_short Increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
title_sort increasing mapping precision of genome-wide association studies: to genotype and impute, sequence, or both?
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474869/
https://www.ncbi.nlm.nih.gov/pubmed/28629446
http://dx.doi.org/10.1186/s13059-017-1255-6
work_keys_str_mv AT wangzhaoming increasingmappingprecisionofgenomewideassociationstudiestogenotypeandimputesequenceorboth
AT chatterjeenilanjan increasingmappingprecisionofgenomewideassociationstudiestogenotypeandimputesequenceorboth

Ejemplares similares