β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections

Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans...

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Detalles Bibliográficos
Autores principales: Grassmé, Heike, Henry, Brian, Ziobro, Regan, Becker, Katrin Anne, Riethmüller, Joachim, Gardner, Aaron, Seitz, Aaron P., Steinmann, Joerg, Lang, Stephan, Ward, Christopher, Schuchman, Edward H., Caldwell, Charles C., Kamler, Markus, Edwards, Michael J., Brodlie, Malcolm, Gulbins, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475347/
https://www.ncbi.nlm.nih.gov/pubmed/28552668
http://dx.doi.org/10.1016/j.chom.2017.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475347/
https://www.ncbi.nlm.nih.gov/pubmed/28552668
http://dx.doi.org/10.1016/j.chom.2017.05.001

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