Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib

EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally,...

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Detalles Bibliográficos
Autores principales: Ai, Chun-Zhi, Liu, Yong, Li, Wei, Chen, De-Meng, Zhu, Xin-Xing, Yan, Ya-Wei, Chen, Du-Chu, Jiang, Yi-Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476264/
https://www.ncbi.nlm.nih.gov/pubmed/28628631
http://dx.doi.org/10.1371/journal.pone.0179333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476264/
https://www.ncbi.nlm.nih.gov/pubmed/28628631
http://dx.doi.org/10.1371/journal.pone.0179333

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