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Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner

Symplekin is a multifunctional protein that localizes to both tight junctions and the nucleus in polarized epithelial cells, with confirmed roles in mRNA maturation, transcriptional modulation and tight-junction assembly. However, the mechanisms governing its subcellular distribution and related fun...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Mao, Hai-Lei, Cao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476558/
https://www.ncbi.nlm.nih.gov/pubmed/28630428
http://dx.doi.org/10.1038/s41598-017-04005-z