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Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines
Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibody titer comparing monomeric and nano-arrayed antigen. Ther...
Autores principales: | Leneghan, Darren B., Miura, Kazutoyo, Taylor, Iona J., Li, Yuanyuan, Jin, Jing, Brune, Karl D., Bachmann, Martin F., Howarth, Mark, Long, Carole A., Biswas, Sumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476561/ https://www.ncbi.nlm.nih.gov/pubmed/28630474 http://dx.doi.org/10.1038/s41598-017-03798-3 |
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