Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death

Stress induced BSA (bovine serum albumin) protein aggregation is effectively mitigated in vitro by TUDCA (tauroursodeoxycholic acid) than by PBA (4- phenylbutyric acid), chemical chaperones approved by FDA for the treatment of biliary cirrhosis and urea cycle disorders respectively. TUDCA, unlike PB...

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Detalles Bibliográficos
Autores principales: Uppala, Jagadeesh Kumar, Gani, Amina R., Ramaiah, Kolluru V. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476595/
https://www.ncbi.nlm.nih.gov/pubmed/28630443
http://dx.doi.org/10.1038/s41598-017-03940-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476595/
https://www.ncbi.nlm.nih.gov/pubmed/28630443
http://dx.doi.org/10.1038/s41598-017-03940-1

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