The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells

Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and underlying mechanisms are not clear. Our previous study revealed that ADR increased reactive oxygen species (ROS) generation and decreased g...

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Detalles Bibliográficos
Autores principales: Ge, Chun, Cao, Bei, Feng, Dong, Zhou, Fang, Zhang, Jingwei, Yang, Na, Feng, Siqi, Wang, Guangji, Aa, Jiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476638/
https://www.ncbi.nlm.nih.gov/pubmed/28630426
http://dx.doi.org/10.1038/s41598-017-03881-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476638/
https://www.ncbi.nlm.nih.gov/pubmed/28630426
http://dx.doi.org/10.1038/s41598-017-03881-9

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