Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level of mRNA translation under such conditions. We sought to addre...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatanaka, Masayuki, Anderson-Baucum, Emily, Lakhter, Alexander, Kono, Tatsuyoshi, Maier, Bernhard, Tersey, Sarah A., Tanizawa, Yukio, Evans-Molina, Carmella, Mirmira, Raghavendra G., Sims, Emily K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476640/
https://www.ncbi.nlm.nih.gov/pubmed/28630491
http://dx.doi.org/10.1038/s41598-017-03869-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476640/
https://www.ncbi.nlm.nih.gov/pubmed/28630491
http://dx.doi.org/10.1038/s41598-017-03869-5

Ejemplares similares