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Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation
Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level of mRNA translation under such conditions. We sought to addre...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476640/ https://www.ncbi.nlm.nih.gov/pubmed/28630491 http://dx.doi.org/10.1038/s41598-017-03869-5 |