Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation

Influenza viruses are a major public health threat worldwide. The influenza hemagglutinin (HA) plays an essential role in the virus life cycle. Due to the high conservation of the HA stem region, it has become an especially attractive target for inhibitors for therapeutics. In this study, molecular...

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Detalles Bibliográficos
Autores principales: Guan, Shanshan, Wang, Tianao, Kuai, Ziyu, Qian, Mengdan, Tian, Xiaopian, Zhang, Xiuqi, Yu, Yongjiao, Wang, Song, Zhang, Hao, Li, Hao, Kong, Wei, Shan, Yaming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476670/
https://www.ncbi.nlm.nih.gov/pubmed/28630402
http://dx.doi.org/10.1038/s41598-017-03719-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476670/
https://www.ncbi.nlm.nih.gov/pubmed/28630402
http://dx.doi.org/10.1038/s41598-017-03719-4

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