Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways

Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunisti...

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Detalles Bibliográficos
Autores principales: Rodríguez-Arce, Irene, Martí, Sara, Euba, Begoña, Fernández-Calvet, Ariadna, Moleres, Javier, López-López, Nahikari, Barberán, Montserrat, Ramos-Vivas, José, Tubau, Fe, Losa, Carmen, Ardanuy, Carmen, Leiva, José, Yuste, José E., Garmendia, Junkal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476696/
https://www.ncbi.nlm.nih.gov/pubmed/28676846
http://dx.doi.org/10.3389/fcimb.2017.00266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476696/
https://www.ncbi.nlm.nih.gov/pubmed/28676846
http://dx.doi.org/10.3389/fcimb.2017.00266

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