p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

Disrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms involved in these processes are largely unknown. Here we show that cardiac activation of p38γ and p38δ increases during postnatal development...

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Detalles Bibliográficos
Autores principales: González-Terán, Bárbara, López, Juan Antonio, Rodríguez, Elena, Leiva, Luis, Martínez-Martínez, Sara, Bernal, Juan Antonio, Jiménez-Borreguero, Luis Jesús, Redondo, Juan Miguel, Vazquez, Jesús, Sabio, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476828/
https://www.ncbi.nlm.nih.gov/pubmed/26795633
http://dx.doi.org/10.1038/ncomms10477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476828/
https://www.ncbi.nlm.nih.gov/pubmed/26795633
http://dx.doi.org/10.1038/ncomms10477

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