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Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor

Most nuclear receptors (NRs) bind DNA as dimers, either as hetero- or as homodimers on DNA sequences organized as two half-sites with specific orientation and spacing. The dimerization of NRs on their cognate response elements (REs) involves specific protein–DNA and protein–protein interactions. The...

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Detalles Bibliográficos
Autores principales: Mohideen-Abdul, Kareem, Tazibt, Karima, Bourguet, Maxime, Hazemann, Isabelle, Lebars, Isabelle, Takacs, Maria, Cianférani, Sarah, Klaholz, Bruno P., Moras, Dino, Billas, Isabelle M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476932/
https://www.ncbi.nlm.nih.gov/pubmed/28676789
http://dx.doi.org/10.3389/fendo.2017.00140