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Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics
[Image: see text] A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization. The double-mercapto input is proposed for use in the Ugi reaction, thereby yielding all six top...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477004/ https://www.ncbi.nlm.nih.gov/pubmed/28581763 http://dx.doi.org/10.1021/acs.orglett.7b01324 |