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Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics

[Image: see text] A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization. The double-mercapto input is proposed for use in the Ugi reaction, thereby yielding all six top...

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Detalles Bibliográficos
Autores principales:	Vishwanatha, Thimmalapura M., Bergamaschi, Enrico, Dömling, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477004/ https://www.ncbi.nlm.nih.gov/pubmed/28581763 http://dx.doi.org/10.1021/acs.orglett.7b01324

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