Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases

Inhibitors of sulfatase-2 are putative anticancer agents, but the discovery of potent small molecules targeting this enzyme has proved challenging. Based on molecular modelling, two series of sulfatase-2 inhibitors have been developed with biphenyl and biphenyl ether scaffolds judiciously substitute...

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Detalles Bibliográficos
Autores principales: Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477036/
https://www.ncbi.nlm.nih.gov/pubmed/28660059
http://dx.doi.org/10.1039/c5sc03612g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477036/
https://www.ncbi.nlm.nih.gov/pubmed/28660059
http://dx.doi.org/10.1039/c5sc03612g

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