Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

BACKGROUND: ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in the morning during the study, simulation can allow the antiresorptive effect to b...

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Detalles Bibliográficos
Autores principales: Tanaka, Makoto, Hashimoto, Yoshitaka, Hasegawa, Chihiro, Deacon, Steve, Eastell, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477094/
https://www.ncbi.nlm.nih.gov/pubmed/28629344
http://dx.doi.org/10.1186/s12891-017-1625-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477094/
https://www.ncbi.nlm.nih.gov/pubmed/28629344
http://dx.doi.org/10.1186/s12891-017-1625-y

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