Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

BACKGROUND: T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) and programmed cell death protein 1 (PD-1) are important inhibitory receptors that associate with T cell exhaustion in acute myeloid leukemia (AML). In this study, we aimed to determine the und...

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Detalles Bibliográficos
Autores principales: Zhu, Liuluan, Kong, Yaxian, Zhang, Jianhong, Claxton, David F., Ehmann, W. Christopher, Rybka, Witold B., Palmisiano, Neil D., Wang, Ming, Jia, Bei, Bayerl, Michael, Schell, Todd D., Hohl, Raymond J., Zeng, Hui, Zheng, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477125/
https://www.ncbi.nlm.nih.gov/pubmed/28629373
http://dx.doi.org/10.1186/s13045-017-0486-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477125/
https://www.ncbi.nlm.nih.gov/pubmed/28629373
http://dx.doi.org/10.1186/s13045-017-0486-z

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