β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

Mechanisms of acute pain transition to chronic pain are not fully understood. Here we demonstrate an active role of β-arrestin 2 (Arrb2) in regulating spinal cord NMDA receptor (NMDAR) function and the duration of pain. Intrathecal injection of the mu-opioid receptor agonist [D-Ala(2), NMe-Phe(4), G...

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Detalles Bibliográficos
Autores principales: Chen, Gang, Xie, Rou-Gang, Gao, Yong-Jing, Xu, Zhen-Zhong, Zhao, Lin-Xia, Bang, Sangsu, Berta, Temugin, Park, Chul-Kyu, Lay, Mark, Chen, Wei, Ji, Ru-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477285/
https://www.ncbi.nlm.nih.gov/pubmed/27538456
http://dx.doi.org/10.1038/ncomms12531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477285/
https://www.ncbi.nlm.nih.gov/pubmed/27538456
http://dx.doi.org/10.1038/ncomms12531

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