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Modelling proteins’ hidden conformations to predict antibiotic resistance

TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify hidden conformations and explore their role in det...

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Detalles Bibliográficos
Autores principales: Hart, Kathryn M., Ho, Chris M. W., Dutta, Supratik, Gross, Michael L., Bowman, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477488/
https://www.ncbi.nlm.nih.gov/pubmed/27708258
http://dx.doi.org/10.1038/ncomms12965