Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence

Efforts to recapitulate haematopoiesis, a process guided by spatial and temporal inductive signals, to generate haematopoietic progenitors from human pluripotent stem cells (hPSCs) have focused primarily on exogenous signalling pathway activation or inhibition. Here we show haemogenic niches can be...

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Detalles Bibliográficos
Autores principales: Rahman, Nafees, Brauer, Patrick M., Ho, Lilian, Usenko, Tatiana, Tewary, Mukul, Zúñiga-Pflücker, Juan Carlos, Zandstra, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477512/
https://www.ncbi.nlm.nih.gov/pubmed/28541275
http://dx.doi.org/10.1038/ncomms15380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477512/
https://www.ncbi.nlm.nih.gov/pubmed/28541275
http://dx.doi.org/10.1038/ncomms15380

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