Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a lysosomal storage disorder, neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests that PGRN is essential for prope...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaolai, Sun, Lirong, Bracko, Oliver, Choi, Ji Whae, Jia, Yan, Nana, Alissa L., Brady, Owen Adam, Hernandez, Jean C. Cruz, Nishimura, Nozomi, Seeley, William W., Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477518/
https://www.ncbi.nlm.nih.gov/pubmed/28541286
http://dx.doi.org/10.1038/ncomms15277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477518/
https://www.ncbi.nlm.nih.gov/pubmed/28541286
http://dx.doi.org/10.1038/ncomms15277

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