Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain

Oxidative modification of the voltage-gated potassium (K(+)) channel KCNB1 promotes apoptosis in the neurons of cortex and hippocampus through a signaling pathway mediated by Src tyrosine kinases. How oxidation of the channel is transduced into Src recruitment and activation, however, was not known....

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Detalles Bibliográficos
Autores principales: Yu, Wei, Gowda, Manasa, Sharad, Yashsavi, Singh, Surindo A, Sesti, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477583/
https://www.ncbi.nlm.nih.gov/pubmed/28383553
http://dx.doi.org/10.1038/cddis.2017.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477583/
https://www.ncbi.nlm.nih.gov/pubmed/28383553
http://dx.doi.org/10.1038/cddis.2017.160

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