P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury

Glaucoma is a leading cause of irreversible blindness worldwide that is characterized by progressive retinal ganglion cell (RGC) death. However, RGC senescence as a phase before RGC death, and the mechanism of RGC senescence remains unclear. Here, we demonstrate that TANK-binding protein 1 (TBK1) is...

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Detalles Bibliográficos
Autores principales: Li, L u, Zhao, Yin, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477587/
https://www.ncbi.nlm.nih.gov/pubmed/28425986
http://dx.doi.org/10.1038/cddis.2017.169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477587/
https://www.ncbi.nlm.nih.gov/pubmed/28425986
http://dx.doi.org/10.1038/cddis.2017.169

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