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P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury
Glaucoma is a leading cause of irreversible blindness worldwide that is characterized by progressive retinal ganglion cell (RGC) death. However, RGC senescence as a phase before RGC death, and the mechanism of RGC senescence remains unclear. Here, we demonstrate that TANK-binding protein 1 (TBK1) is...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477587/ https://www.ncbi.nlm.nih.gov/pubmed/28425986 http://dx.doi.org/10.1038/cddis.2017.169 |