Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane

PURPOSE: The mutation R345W in EFEMP1 (fibulin-3) causes macular degeneration. This study sought to determine whether proteoglycan content and diffusion across Bruch's membrane are altered in Efemp1(ki/ki) mice carrying this mutation or in Efemp1(−/−) mice. METHODS: Proteoglycans in mouse Bruch...

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Detalles Bibliográficos
Autores principales: Zayas-Santiago, Astrid, Cross, Samuel D., Stanton, James B., Marmorstein, Alan D., Marmorstein, Lihua Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477800/
https://www.ncbi.nlm.nih.gov/pubmed/28622396
http://dx.doi.org/10.1167/iovs.17-21720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477800/
https://www.ncbi.nlm.nih.gov/pubmed/28622396
http://dx.doi.org/10.1167/iovs.17-21720

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